GOF

GOF may refer to:
 * Gain-of-function, a property of a genetic mutation that changes the gene product such that its effect gets stronger (enhanced activation) or even is superseded by a different and abnormal function
 * Galaxy on Fire, a video game series
 * Gamers Outreach Foundation, an American philanthropic organization
 * Gamo-Gofa-Dawro language, native to Ethiopia
 * Gang of Four (disambiguation)
 * General Operations Force, of the Malaysian police
 * Golf Street railway station, in Angus, Scotland
 * Goodness of fit
 * Grand Orient de France, a Masonic organization in France
 * Gulf of Finland
 * Harry Potter and the Goblet of Fire, a 2000 novel by J. K. Rowling