GRB2-associated-binding protein 1

GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene.

Function
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. The encoded protein is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.

Interactions
GAB1 has been shown to interact with:


 * CRKL,
 * Grb2,
 * MAP3K3,
 * PIK3R1,
 * PLCG1 and
 * PTPN11.