GTPase-activator protein for Ras-like GTPase

GTPase-activator protein for Ras-like GTPase is a family of evolutionarily related proteins. Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP. This intrinsic GTPase activity of ras is stimulated by a family of proteins collectively known as 'GAP' or GTPase-activating proteins. As it is the GTP bound form of ras which is active, these proteins are said to be down-regulators of ras.

The Ras GTPase-activating proteins are quite large (from 765 residues for sar1 to 3079 residues for IRA2) but share only a limited (about 250 residues) region of sequence similarity, referred to as the 'catalytic domain' or rasGAP domain.

Note: There are distinctly different GAPs for the rap and rho/rac subfamilies of ras-like proteins (reviewed in reference ) that do not share sequence similarity with ras GAPs.

Examples
Human genes encoding proteins containing this domain include:
 * DAB2IP;
 * GAPVD1;
 * IQGAP1;   IQGAP2;    IQGAP3;
 * NF1;
 * RASA1;    RASA2;     RASA3;     RASA4;     RASAL1;    RASAL2;
 * SYNGAP1;