Galactoside 2-alpha-L-fucosyltransferase

In enzymology, a galactoside 2-alpha-L-fucosyltransferase is an enzyme that catalyzes the chemical reaction


 * GDP-beta-L-fucose + beta-D-galactosyl-R $$\rightleftharpoons$$ GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R

Thus, the two substrates of this enzyme are GDP-beta-L-fucose and beta-D-galactosyl-R, whereas its two products are GDP and alpha-L-fucosyl-1,2-beta-D-galactosyl-R.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. This enzyme participates in 4 metabolic pathways: glycosphingolipid biosynthesis - lactoseries, glycosphingolipid biosynthesis - neo-lactoseries, glycosphingolipid biosynthesis - globoseries, and glycan structures - biosynthesis 2.

Nomenclature
The systematic name of this enzyme class is: Other names in common use include:
 * GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase
 * blood group H alpha-2-fucosyltransferase
 * guanosine diphosphofucose-galactoside 2-L-fucosyltransferase
 * alpha-(1->2)-L-fucosyltransferase
 * alpha-2-fucosyltransferase
 * alpha-2-L-fucosyltransferase
 * blood-group substance H-dependent fucosyltransferase
 * guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase
 * guanosine diphosphofucose-lactose fucosyltransferase
 * GDP fucose-lactose fucosyltransferase
 * guanosine diphospho-L-fucose-lactose fucosyltransferase
 * guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase
 * guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide
 * alpha-L-fucosyltransferase, guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase
 * H-gene-encoded beta-galactoside alpha1->2fucosyltransferase
 * secretor-type beta-galactoside alpha1->2fucosyltransferase
 * beta-galactoside alpha1->2fucosyltransferase
 * GDP-L-fucose:lactose fucosyltransferase