Gender dysphoria in children

Gender dysphoria in children (GD), also known as gender incongruence of childhood, is a formal diagnosis for children who experience significant discontent (gender dysphoria) due to a mismatch between their assigned sex and gender identity. The diagnostic label gender identity disorder in children (GIDC) was used by the Diagnostic and Statistical Manual of Mental Disorders (DSM) until it was renamed gender dysphoria in children in 2013 with the release of the DSM-5. The diagnosis was renamed to remove the stigma associated with the term disorder.

Classification
Children with persistent gender dysphoria are characterized by more extreme gender dysphoria in childhood than children with desisting gender dysphoria. Some (but not all) gender variant youth will want or need to transition, which may involve social transition (changing dress, name, pronoun), and, for older youth and adolescents, medical transition (hormone therapy or surgery).

DSM-5
The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) published by the American Psychiatric Association in 2013 introduced a diagnosis of Gender Dysphoria in Children.

Compared to the prior diagnosis of GIDC in the DSM-IV, subtyping by sexual orientation was deleted. The diagnosis for children was separated from that for adults. The creation of a specific diagnosis for children reflects the lesser ability of children to have insight into what they are experiencing, or ability to express it in the event that they have insight. Further, the DSM-5 considered non-binary gender identities.

The main diagnostic criterion is a marked incongruence between experienced/expressed gender and assigned gender, of at least six months duration, as manifested by at least six of the following (one of which must be the first criterion):
 * A strong desire to be of the other gender or an insistence that one is the other gender
 * A strong preference for wearing clothes typical of the opposite gender
 * A strong preference for cross-gender roles in make-believe play or fantasy play
 * A strong preference for the toys, games or activities stereotypically used or engaged in by the other gender
 * A strong preference for playmates of the other gender
 * A strong rejection of toys, games and activities typical of one's assigned gender
 * A strong dislike of one's sexual anatomy
 * A strong desire for the physical sex characteristics that match one's experienced gender

In order to meet the criteria, the condition must also be associated with clinically significant distress or impairment in social, occupational, or other important areas of functioning.

International Classification of Diseases (ICD)
The International Classification of Diseases (ICD-11) lists "gender incongruence" under "conditions related to sexual health", which is coded into three conditions:
 * Gender incongruence of adolescence or adulthood (HA60): replaces F64.0
 * Gender incongruence of childhood (HA61): replaces F64.2
 * Gender incongruence, unspecified (HA6Z): replaces F64.9

The previous version of the International Classification of Diseases, ICD-10, used to have five different diagnoses for "gender identity disorder", including one for when it manifests during childhood. The diagnoses of gender identity disorder were not given to intersex individuals (those born with "ambiguous" genitalia). Additionally, as with all psychological disorders, these symptoms must cause direct distress and an impairment of functioning of the individual exhibiting the symptoms.

F64.2 Gender identity disorder of childhood
A disorder, usually first manifest during early childhood (and always well before puberty), characterized by a persistent and intense distress about assigned sex, together with a desire to be (or insistence that one is) of the other sex. There is a persistent preoccupation with the dress and activities of the opposite sex and repudiation of the individual's own sex. The diagnosis requires a profound disturbance of the normal gender identity; mere tomboyishness in girls or girlish behavior in boys is not sufficient. Gender identity disorders in individuals who have reached or are entering puberty should not be classified here but in F66.0.

Persistence
According to the American Academy of Pediatrics, most children have a stable sense of their gender identity by age 4. They explain that research shows prepubertal children who assert a transgender or gender diverse identity know their gender as clearly and as consistently as their cisgender peers. Gender dysphoria in children sometimes persists into and throughout adulthood, while for others it desists by that time. Retrospective studies suggest that 12-27% of cases would persist into adulthood, though multiple factors complicate attempts to study the persistence rate. Critics have argued these rates are innacurate due to loss of follow-up participants and misclassification as not transgender, changing criteria for gender dysphoria, and referrals of youth to gender clinics for gender-nonconforming behavior as opposed to gender dysphoria. Other research has shown that if gender dysphoria persists during puberty, it is very likely permanent. Factors that are associated with gender dysphoria persisting through puberty include intensity of gender dysphoria, amount of cross-gendered behavior, and verbal identification with the desired/experienced gender (i.e. stating that they are a different gender rather than wish to be a different gender).

Some studies have found that gender dysphoria in children is more heavily linked to adult homosexuality than to an adult transgender identity, especially with regard to boys. These studies state that the majority of children diagnosed with gender dysphoria did not desire to be the other sex by puberty, with most growing up to identify as gay, lesbian, or bisexual, with or without therapeutic intervention. However, they have been criticized as irrelevant on the basis that they counted as 'desistance' cases where the child was simply gender-nonconforming rather than dysphoric and tracked diagnoses rather than gender identity or desire to transition, leading to inflation of the desistance statistics. The majority of desistance research relies on four studies published since 2008. While the subjects met the criteria for gender identity disorder as defined in the DSM-III or DSM-IV, many would not have met the updated criteria for gender dysphoria in the DSM-5, established in 2013, which unlike prior versions explicitly requires identification with a gender other than assigned at birth. In one study, 40% of those classified as "desisters" were subthreshold even for the DSM-IV criteria. The four studies all offered evidence that statement of transgender identity in childhood predicted transgender identity in adolescence and adulthood, and the intensity of gender dysphoria in childhood likewise predicted its intensity later in life. The studies published from the 1960–1980's never used the term "desistance", instead focusing on "gender-deviant behavior" - childhood femininity in people assigned male at birth - and how this more often predicts homosexuality rather than "transsexualism" in adulthood. Additionally, some of the research since 2000 and all the research prior has been criticized for citing studies that used conversion therapy, a disproven method consisting of either discouraging social transition, explicitly trying to prevent or discourage the child from identifying as transgender as an adult by adulthood or adolescence, or actively employing techniques to limit their "gender-deviant" behavior. The term "desistance" itself has been criticized as pathologizing for its roots in criminal research and oppositional defiance disorder, where desistance is considered a positive outcome.

A systematic review of research relating to desistance was published in 2022. It found that desistance was poorly defined: studies sometimes did not define it or equally defined it as desistance of transgender identity or desistance of gender dysphoria. They also found none of the definitions allowed for dynamic or nonbinary gender identities and the majority of articles published were editorial pieces. They stated the concept was based on biased research from the 1960-80s and poor quality research in the 2000s. They concluded there was a "dearth of high-quality hypothesis-driven research that currently exists" on the subject, and suggested that desistance should "be removed from clinical and research discourse to focus instead on supporting [transgender and gender-expansive] youth rather than attempting to predict their future gender identity." According to a review published in 2022 considering more recent studies, the majority of pre-pubertal children who socially transition persist in their identity in 5-to 7-year follow-ups, disproving the results of the prior studies.

Prevalence
The numbers of youth self-identifying as transgender rose sharply across the Western world in the 2010s. There was an especially strong increase among birth-registered females, who now comprise a clear majority of cases. Children and adolescents with gender dysphoria are more likely to have autism spectrum condition, ADHD, anxiety, depression, eating disorders and histories of suicidality, self-harm and adverse childhood experiences.

According to a review published in 2020 relying on recent statistical surveys, 1.2% to 2.7% of children and adolescents worldwide identify as transgender. The data was drawn more from studies of adolescents than pre-pubertal youth and noted a difference in methodological quality between studies published before and after 2010. The review called for more systematic studies and reviews in future.

Management
The WPATH Standards of Care and other therapeutic interventions do not seek to change a child's gender identity. Instead, clinicians advise children and their parents to avoid goals based on gender identity and to instead cope with the child's distress by embracing psychoeducation and to be supportive of their gender variant identity and behavior as it develops. A clinician may suggest that the parent be attentive, listen, and encourage an environment for the child to explore and express their identified gender identity, which may be termed the true gender. This can remove the stigma associated with their dysphoria, as well as the pressure to conform to a gender identity or role they do not identify with, which may be termed the false gender self. WPATH Standards of Care also recommend assessing and treating any co-existing mental health issues. The majority of major medical associations define attempts to change an individual's gender identity or gender expression as conversion therapy and strongly discourage it citing concerns of a lack of scientific credibility and clinical utility with these practices.

Treatment may also take the form of puberty blockers (such as leuprorelin), cross-sex hormones (i.e., administering estrogen to a child assigned male at birth or testosterone to a child assigned female at birth), or sex reassignment surgery when the child has reached the age of medical majority, with the aim of bringing one's physical body in line with their identified gender. Delaying puberty allows for the child to mentally mature while preventing them from developing a body they may not want, so that they may make a more informed decision about their gender identity once they are an adolescent. It can also help reduce anxiety and depression. Short-term side effects of puberty blockers include headaches, fatigue, insomnia, muscle aches and changes in breast tissue, mood, and weight. Research on the long-term effects on brain development, cognitive function, fertility, and sexual function is limited.

According to the American Psychiatric Association, "Due to the dynamic nature of puberty development, lack of gender-affirming interventions (i.e. social, psychological, and medical) is not a neutral decision; youth often experience worsening dysphoria and negative impact on mental health as the incongruent and unwanted puberty progresses. Trans-affirming treatment, such as the use of puberty suppression, is associated with the relief of emotional distress, and notable gains in psychosocial and emotional development, in trans and gender diverse youth".

In its position statement published December 2020, the Endocrine Society stated that there is durable evidence for a biological underpinning to gender identity and that pubertal suppression, hormone therapy, and medically indicated surgery are effective and relatively safe when monitored appropriately and have been established as the standard of care. They noted a decrease in suicidal ideation among youth who have access to gender-affirming care and comparable levels of depression to cisgender peers among socially transitioned pre-pubertal youth. In its 2017 guideline on treating those with gender dysphoria, it recommends puberty blockers be started when the child has started puberty (Tanner Stage 2 for breast or genital development) and cross-sex hormones be started at 16, though they note "there may be compelling reasons to initiate sex hormone treatment prior to the age of 16 years in some adolescents with GD/gender incongruence". They recommend a multidisciplinary team of medical and mental health professionals manage the treatment for those under 18. They also recommend "monitoring clinical pubertal development every 3 to 6 months and laboratory parameters every 6 to 12 months during sex hormone treatment".

For adolescents, WPATH says that physical interventions such as puberty blockers, hormone therapy, or surgery may be appropriate. Before any physical interventions are initiated, however, a psychiatric assessment exploring the psychological, family, and social issues around the adolescent's gender dysphoria should be undertaken. WPATH's Standards of Care 8, published in 2022, declare puberty blocking medication as "medically necessary", and recommends them for usage in transgender adolescents once the patient has reached Tanner stage 2 of development, and state that longitudinal shows improved outcomes for transgender patients who receive them.

While few studies have examined the effects of puberty blockers for gender non-conforming or transgender adolescents, the studies that have been conducted generally indicate that these treatments are reasonably safe, are reversible, and can improve psychological well-being.

A 2020 review published in Child and Adolescent Mental Health found that puberty blockers are reversible and associated with such positive outcomes as decreased suicidality in adulthood, improved affect and psychological functioning, and improved social life. A 2020 survey published in Pediatrics found that puberty blockers are associated with better mental health outcomes and lower odds of lifetime suicidal ideation. A 2022 study published in the Journal of the American Medical Association found a 60% reduction in moderate and severe depression and a 73% reduction in suicidality among transgender youth aged 13–20 who took puberty blockers and gender-affirming hormones over a 12-month follow-up. A 2022 study published in The Lancet involving 720 transgender adolescents who took puberty blockers and hormones found that 98 percent continued to use hormones at a follow-up appointment.

In 2020, a review article commissioned by NHS England was published by the National Institute for Health and Care Excellence, concluding that the quality of evidence for puberty blocker outcomes (for mental health, quality of life and impact on gender dysphoria) was of very low certainty based on the GRADE scale. The Finnish government commissioned a review of the research evidence for treatment of minors and the Finnish Ministry of Health concluded that there are no research-based health care methods for minors with gender dysphoria. Nevertheless, they recommend the use of puberty blockers for minors on a case-by-case basis, and the American Academy of Pediatrics state that "pubertal suppression in children who identify as TGD [transgender and gender diverse] generally leads to improved psychological functioning in adolescence and young adulthood." The National Board of Health and Welfare in Sweden took similar action in 2022.

In 2024, NHS England endorsed the Cass Review of gender treatment for children and young people, which questioned the reliability of existing guidelines and made various recommendations. The review has received criticism from some international medical organisations.