George O'Brien

George O'Brien may refer to:


 * George O'Brien (actor) (1899–1985), American film actor
 * George O'Brien (baseball) (1889–1966), American baseball player
 * George O'Brien (cricketer) (born 1984), Bermudian cricketer
 * George O'Brien (cyclist) (born 1935), British cyclist
 * George O'Brien (footballer, born 1935) (1935–2020), Scottish football player for Dunfermline Athletic, Leeds United and Southampton
 * George O'Brien (1900s footballer), English football player for Manchester United
 * George O'Brien (Irish politician) (1892–1973), Irish politician, economist and academic
 * George O'Brien (painter) (1821–1888), New Zealand painter
 * George O'Brien (writer) (born 1945), Irish academic and writer of short fiction and memoir
 * George D. O'Brien (1900–1957), U.S. Representative from Michigan
 * G. Dennis O'Brien (born 1931), former president of the University of Rochester
 * George H. O'Brien Jr. (1926–2005), Korean War Medal of Honor recipient
 * George M. O'Brien (1917–1986), U.S. Representative from Illinois
 * George Thomas Michael O'Brien (1844–1906), governor of Fiji, governor of Hong Kong, High Commissioner for the Western Pacific
 * George O'Brien, a fictional politician in the Kingston Trio song "M.T.A."