George Spencer

George Spencer may refer to:
 * George Spencer (c. 1600–1642), first white man to be executed in Connecticut, see Execution of George Spencer
 * George Spencer, 4th Duke of Marlborough (1739–1817), British courtier and politician
 * George Spencer, 2nd Earl Spencer (1758–1834), British Whig politician
 * Ignatius Spencer (1799–1864), son of 2nd Earl Spencer, known as George Spencer before entering the Passionist congregation
 * George Spencer (bishop) (1799–1866), Anglican bishop
 * George E. Spencer (1836–1893), U.S. senator from the state of Alabama
 * George Spencer (Labour politician) (1872–1957), Member of Parliament for Broxtowe, 1918–1929
 * George Lloyd Spencer (1893–1981), Democratic United States senator from the state of Arkansas
 * George Spencer (baseball) (1926–2014), American baseball pitcher
 * George Spencer (rugby) (1878–1950), New Zealand rugby football player
 * George Soule Spencer, American actor
 * SS George Spencer, a wooden lake freighter