Glucose-1-phosphate thymidylyltransferase

In enzymology, a glucose-1-phosphate thymidylyltransferase is an enzyme that catalyzes the chemical reaction


 * dTTP + alpha- D -glucose 1-phosphate $$\rightleftharpoons$$ diphosphate + dTDP-glucose

Thus, the two substrates of this enzyme are dTTP and alpha- D -glucose 1-phosphate, whereas its two products are pyrophosphate and dTDP-glucose.

This enzyme belongs to the family of transferases, to be specific, those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). This enzyme participates in 3 metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar unit biosynthesis.

Nomenclature
The systematic name of this enzyme class is dTTP:alpha- D -glucose-1-phosphate thymidylyltransferase. Other names in common use include:
 * glucose 1-phosphate thymidylyltransferase,
 * dTDP-glucose synthase, dTDP-glucose pyrophosphorylase,
 * thymidine diphosphoglucose pyrophosphorylase,
 * thymidine diphosphate glucose pyrophosphorylase, and
 * TDP-glucose pyrophosphorylase.

Structural studies
As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , , , , , , , , , , and.