Glycosylphosphatidylinositol diacylglycerol-lyase

The enzyme glycosylphosphatidylinositol diacylglycerol-lyase (EC 4.6.1.14) catalyzes the reaction


 * 6-(α- D -glucosaminyl)-1-phosphatidyl-1 D -myo-inositol = 6-(α- D -glucosaminyl)-1 D -myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol

This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is 6-(α- D -glucosaminyl)-1-phosphatidyl-1 D -myo-inositol 1,2-diacyl-sn-glycerol-lyase [6-(α- D -glucosaminyl)-1 D -myo-inositol 1,2-cyclic phosphate-forming]. Other names in common use include (glycosyl)phosphatidylinositol-specific phospholipase C, GPI-PLC, GPI-specific phospholipase C, VSG-lipase, glycosyl inositol phospholipid anchor-hydrolyzing enzyme, glycosylphosphatidylinositol-phospholipase C, glycosylphosphatidylinositol-specific phospholipase C, variant-surface-glycoprotein phospholipase C, 6-(α- D -glucosaminyl)-1-phosphatidyl-1 D -myo-inositol, and diacylglycerol-lyase (1,2-cyclic-phosphate-forming).