Glycosylphosphatidylinositol phospholipase D

Glycosylphosphatidylinositol phospholipase D (EC 3.1.4.50, GPI-PLD, glycoprotein phospholipase D, phosphatidylinositol phospholipase D, phosphatidylinositol-specific phospholipase D) is an enzyme with systematic name glycoprotein-phosphatidylinositol phosphatidohydrolase. This enzyme catalyses the following chemical reaction


 * 6-(α- D -glucosaminyl)-1-phosphatidyl-1 D -myoinositol + H2O $$\rightleftharpoons$$ 6-(α- D -glucosaminyl)-1 D -myo-inositol + 3-sn-phosphatidate

This enzyme cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors.