Goblet cell carcinoid

The goblet cell carcinoid (GCC) is a rare biphasic gastrointestinal tract tumour that consists of a neuroendocrine component and a conventional carcinoma, histologically arising from Paneth cells.

Sign and symptoms
GCCs may present as appendicitis.

Diagnosis
GCCs are diagnosed by pathology. They have a characteristic biphasic appearance which includes (1) goblet cell-like cells, and (2) neuroendocrine-type nuclear chromatin (stippled chromatin).

Prognosis
GCCs have an aggressive course compared to other appendiceal neuroendocrine tumours.

Treatment
GCCs are treated with surgery.