Golden Globe Award for Best Actor in a Motion Picture – Musical or Comedy

The Golden Globe Award for Best Actor in a Motion Picture – Musical or Comedy is a Golden Globe Award presented annually by the Hollywood Foreign Press Association. It is given in honor of an actor who has delivered an outstanding performance in a leading role in a musical or comedy film. Previously, there was a single award for "Best Actor in a Motion Picture", but the creation of the category in 1951 allowed for recognition of it and the Best Actor – Drama.

The formal title has varied since its inception. In 2006, it was officially called: "Best Performance by an Actor in a Motion Picture – Musical or Comedy". , the wording is "Best Actor in a Motion Picture – Musical or Comedy".

Multiple character nominations
Winners are in bold.
 * Inspector Jacques Clouseau from The Pink Panther (Peter Sellers, 1963), The Return of the Pink Panther (Peter Sellers, 1975) and The Pink Panther Strikes Again (Peter Sellers, 1976)
 * Willy Wonka from Willy Wonka & the Chocolate Factory (Gene Wilder, 1971), Charlie and the Chocolate Factory (Johnny Depp, 2005) and Wonka (Timothée Chalamet, 2023)