Great New York State Marathon

The Great New York State Marathon is an annual marathon 26.2 mi held each October in Syracuse, New York. The first running of the race, previously known as the Empire State Marathon, was on October 16, 2011. The marathon course has been certified by the USATF. In spring of 2021, the race was purchased by Kelleigh's Cause, a 501(c)(3) charity dedicated to raising funds for medical research and awareness for the rare disease Arteriovenous Malformations, with the intention of becoming a charity fundraising race. The marathon took on its current name following purchase. It consists of a weekend of races, including a 5K and 10K on Saturday, and a half and full marathon on Sunday, that start near the New York State Fairgrounds and loops around Onondaga Lake.

In addition to the Great New York State Marathon, Kelleigh's Cause also hosts a 5K/10K in July, also near Onondaga Lake in Syracuse.