Grey's Anatomy season 5

The fifth season of the American television medical drama Grey's Anatomy, created by Shonda Rhimes, commenced airing on American Broadcasting Company (ABC) in the United States on September 25, 2008 and concluded on May 14, 2009 with 24 aired episodes. The season follows the story of a group of surgeons as they go through their residency, while they also deal with the personal challenges and relationships with their mentors. Season 5 had 13 series regulars with 12 of them returning from the previous season, out of which 8 are part of the original cast. The season aired in the Thursday night time-slot at 9:00 pm. The season was officially released on DVD as a seven disc boxset under the title of Grey's Anatomy: The Complete Fifth Season – More Moments on September 9, 2009 by Buena Vista Home Entertainment.

Episodes
The number in the "No. overall" column refers to the episode's number within the overall series, whereas the number in the "No. in season" column refers to the episode's number within this particular season. "U.S. viewers in millions" refers to the number of Americans in millions who watched the episodes live. The fifth season's episodes are altogether 1080 minutes in length. Each episode of this season is named after a song.

Main

 * Ellen Pompeo as Dr. Meredith Grey
 * Sandra Oh as Dr. Cristina Yang
 * Katherine Heigl as Dr. Izzie Stevens
 * Justin Chambers as Dr. Alex Karev
 * T. R. Knight as Dr. George O'Malley
 * Chandra Wilson as Dr. Miranda Bailey
 * James Pickens Jr. as Dr. Richard Webber
 * Sara Ramirez as Dr. Callie Torres
 * Eric Dane as Dr. Mark Sloan
 * Chyler Leigh as Dr. Lexie Grey
 * Brooke Smith as Dr. Erica Hahn
 * Kevin McKidd as Dr. Owen Hunt
 * Patrick Dempsey as Dr. Derek Shepherd

Recurring

 * Kate Walsh as Dr. Addison Montgomery
 * Jessica Capshaw as Dr. Arizona Robbins
 * Jeffrey Dean Morgan as Denny Duquette
 * Brandon Scott as Dr. Ryan Spalding
 * Melissa George as Dr. Sadie Harris
 * Steven W. Bailey as Joe the Bartender
 * Kimberly Elise as Rebecca Swender
 * Eric Stoltz as William Dunn
 * Mary McDonnell as Dr. Virginia Dixon
 * Jennifer Westfeldt as Jen Harmon
 * Ben Shenkman as Rob Harmon
 * Samantha Mathis as Melinda Prescott

Notable guests

 * Tyne Daly as Carolyn Shepherd
 * Audra McDonald as Naomi Bennett
 * Taye Diggs as Sam Bennett
 * Loretta Devine as Adele Webber
 * Héctor Elizondo as Carlos Torres
 * Bernadette Peters as Sarabeth Breyers
 * Faye Dunaway as Margaret Campbell
 * Debra Mooney as Evelyn Hunt
 * Sharon Lawrence as Robbie Stevens
 * Perrey Reeves as Margaret
 * Lauren Stamile as Nurse Rose
 * Robin Pearson Rose as Patricia Murphy
 * Leslie Grossman as Lauren Hammer
 * Liza Weil as Alison Clark
 * Leslie Odom, Jr. as P.J. Walling
 * Nicole Cummins as Paramedic Nicole
 * Grant Show as Archer Montgomery
 * Shannon Lucio as Amanda

a Smith is no longer credited and does not appear after "Rise Up" (5.07). b McKidd is promoted to series regular in the episode "Beat Your Heart Out" (5.14) after previously recurring for 11 episodes, starting with the season premiere. c Dean-Morgan is uncredited in his first appearance of the season "Dream a Little Dream of Me: Part 2" (5.02).

Crew
The season was produced by Touchstone Television ABC Studios, The Mark Gordon Company, ShondaLand, and was distributed by Buena Vista International, Inc. The executive producers were creator Shonda Rhimes, Betsy Beers, Mark Gordon, Krista Vernoff, Rob Corn, Mark Wilding, Joan Rater, and James D. Parriott. The regular directors were Rob Corn, Eric Stoltz, and Tom Verica.

Casting
The fifth season had 13 roles receiving star-billing, with 12 of them returning from the previous season, out of which 8 are part of the original cast from the first season. All of the 13 regulars portray surgeons who work in the fictional Seattle Grace Hospital. Ellen Pompeo continued her role as protagonist and narrator of the series, Dr. Meredith Grey, a resident physician and a surgeon. Sandra Oh played resident Dr. Cristina Yang, best-friend of Meredith and fellow surgeon. Katherine Heigl portrayed resident Dr. Isobel "Izzie" Stevens whose previous relationship with the now-deceased patient Denny Duquette threatens her career once again. Justin Chambers acted as surgical resident Dr. Alexander "Alex" Karev who becomes Izzie's husband, while T. R. Knight portrayed Dr. George O'Malley, an insecure resident whose sensitive personality puts his life in danger. General surgeon and Chief Resident Dr. Miranda Bailey was portrayed by Chandra Wilson, while general surgeon and Chief of Surgery Dr. Richard Webber was played by James Pickens, Jr. Sara Ramirez portrayed orthopedic surgeon Dr. Calliope "Callie" Torres whose storylines during the season revolve around her recently-discovered bisexuality. Eric Dane's character, plastic surgeon Dr. Mark Sloan, begins a relationship with intern Dr. Lexie Grey, Meredith's half-sister portrayed by Chyler Leigh. Brooke Smith appeared in 7 episodes as cardiothoracic surgeon Dr. Erica Hahn, Callie's love-interest, who eventually resigns and moves away. Patrick Dempsey portrayed neurosurgeon Dr. Derek Shepherd whose relationship with Meredith Grey is the series' main storyline.

Although originally introduced as a recurring character in the season premiere, trauma surgeon Dr. Owen Hunt was promoted to a series-regular in the fourteenth episode of the season "Beat Your Heart Out". He was portrayed by Kevin McKidd and was conceived as a love-interest to resident Cristina Yang. Originally only signed onto the show until December 2008, it was later announced Kevin McKidd would be promoted to regular status after his fifth episode on the series aired. He was promoted in the fourteenth episode "Beat Your Heart Out" after 11 guest star appearances. Shonda Rhimes said, "I am excited to have Kevin McKidd joining us for the season, he’s been a delight to collaborate with and brings incredible passion, talent and creativity to his work." Weeks after Hunt's first appearance on the show, Matt Roush of TVGuide comments that "Hunt/McKidd is the most encouraging thing to happen to Grey's Anatomy in quite a while." Robert Rorke of the New York Post states that McKidd was brought in as Hunt to "boost the sagging fortunes" of the show's ratings. Kelley L. Carter of USA Today, describes Hunt as "hardcore" and "the antithesis of the other males on the show."

Numerous supporting characters have been given expansive and recurring appearances in the progressive storyline, including: Melissa George as Sadie Harris, Kimberly Elise as Dr. Jo Swender, Jessica Capshaw as Dr. Arizona Robbins, Amy Madigan as Dr. Wyatt, Mary McDonnell as Dr. Virginia Dixon, Eric Stoltz as William Dunn, Jennifer Westfeldt as Jen Harmon, Ben Shenkman as Rob Harmon, Shannon Lucio as Amanda and Samantha Mathis as Melinda. Héctor Elizondo returned as a guest star in the role of Carlos Torres, Callie's father. Private Practice guest star Grant Show portrays Dr. Archer Montgomery, the brother of former series-regular Dr. Dr. Addison Montgomery in one episode. Shannon Lucio portrays Amanda in the fifth season finale, a witness to the John Doe bus accident in the finale, and returns in the following season's two-part premiere "Good Mourning" and "Goodbye".

In the fifth season, 5 actors were given special guest-star billing, with 3 roles being reprised from a previous season. Jeffrey Dean Morgan returned as the deceased Denny Duquette in Izzie's hallucinations due to a brain tumor. Former series-regular Kate Walsh also returned as Dr. Addison Montgomery for two episodes ("Before and After", "An Honest Mistake") as part of a four-part crossover with her spin-off series, Private Practice. Her fellow cast member Audra McDonald reprises the role of Naomi Bennett from the third season two-parter "The Other Side of This Life", which functioned as a backdoor pilot for the spin-off. She replaces Merrin Dungey in the role, who was recast after the two-part episode aired. McDonald is joined by Taye Diggs as Sam Bennett, who portrays McDonald's ex-husband for the episode "Before and After" as part of the crossover event. Tyne Daly joined the series in the role of Carolyn Shepherd (née Maloney), Derek's mother in the episode "Sympathy for the Devil". This was Daly's only appearance in the series until the fifteenth season episode, "Good Shepherd", which aired in 2019.

Critical response
While few critics weighed in their point of view on the fourth season, several had opinions on the fifth season. Alan Sepinwall from the Newark Star-Ledger said "Overall, it really feels more like the good-old-days than Grey ' s has in a long time" referring to season 5. Also regarding season 5, Misha Davenport from Chicago Sun-Times said "Tonight's premiere hits on all the things the show does so well. There is romance, heartbreak, humor and a few moments that will move fans to tears." Robert Bianco from USA Today said "Happily, it now seems to have landed on solid ground, with its best ensemble and most-engaging stories in years" regarding the show's fifth season.

The return of Izzie's deceased fiancé Denny and the resumption of their romance during the season also proved unpopular with fans, and was deemed "the world's worst storyline" by Mary McNamara of the Los Angeles Times. McNamara was also critical of the episode "Now or Never", which saw Izzie flatline following neurosurgery, opining that Izzie ought to die. The episode in which Izzie married long-term love Alex received 15.3 million viewers, the largest television audience of the night.

Izzie's cancer storyline received a mixed response from the medical community. Otis Brawley, chief medical officer at the American Cancer Society, commented that Izzie's treatment options were unrealistic. Whereas in the show she was offered the drug interleukin-2, in reality the drug is never recommended to patients when melanoma has spread to the brain, as it can cause bleeding and strokes. Brawley explained that such patients would instead be offered radiosurgery. Conversely however, Tim Turnham, executive director of the Melanoma Research Foundation, praised Grey's Anatomy for bringing about greater public awareness of melanoma, stating: "We welcome the national spotlight Grey's Anatomy has created for melanoma and its efforts to encourage viewers to learn more about the importance of prevention, early detection and research."

Accolades
Chandra Wilson won the 2009 NAACP Outstanding Actress in a Drama Series for her portrayal of Dr. Miranda Bailey during the season.

Home Media release
The fifth season was released as a widescreen 7-disc Region 1 DVD box set in the USA on September 15, 2009, with the title Grey's Anatomy: The Complete Fifth Season – More Moments. Each of these releases also contained DVD extras, including footage from behind-the-scenes, deleted scenes and extended episodes. For the U.S & Canada, a special limited box set edition of the season was released exclusively for Target Stores, this box set included an extra disc with over 100 minutes of additional bonus content, including more unaired scenes of the season and crossover episodes with the Grey’s Spin-Off, Private Practice. The season was also released on November 4, 2009 in Region 4 and on August 23, 2010 in Region 2.

A 7-Disc Blu-ray set was originally going to release in Region A alongside the DVD version of the season on September 15, 2009, however, due to unknown reasons the set was never released for the United States & Canada; but the set did get a release for Mexico & Central America on the same day their DVD’s for the season came out. With this release, an exclusive extended version of the episode “Elevator Love Letter” was included among the rest of the special features. For Region B, the Blu-ray was also released, but only for Spain and France.