Guadalupe River

Guadalupe River may refer to:

United States

 * Guadalupe River (California), a tributary of the San Francisco Bay
 * Guadalupe River (Texas), a tributary of the San Antonio Bay of the Gulf of Mexico
 * Guadalupe River State Park, a state park located on a section of the Guadalupe River in Kendall and Comal counties in Texas United States, northwest of Bulverde
 * Rio Guadalupe (New Mexico), a tributary of the Jemez River

Other

 * Guadalupe (Spain), a tributary of the Guadiana in southern Spain