Guthrie Historic District (Guthrie, Kentucky)

The Guthrie Historic District in Guthrie, Kentucky was listed on the National Register of Historic Places in 2011. It is a 12.3 acre area deemed significant "for its connection with the L&N railroad and its associations with transportation in that area. It included 25 contributing buildings, one contributing structure, and two contributing sites, as well as three non-contributing buildings and six noncontributing sites.

Guthrie was founded as a city in 1879, and railroad service was important to the city. Commercial service continues, but passenger railroad service ended in 1957.

Buildings in the district include:
 * Stone House (1898), 106 N. Ewing, a castle-like mansion
 * Rose House (1820), 112 E. Park, adjacent to Stone House, another large house
 * Robert Penn Warren Museum, a home of author Robert Penn Warren
 * Three buildings which, in 2011, were planned to become a railroad museum. In 2022, a railroad museum including a caboose is open by appointment.
 * Abshire Building (1896), 238 S. Ewing St., a brick building which was once three stories tall, and was a salon and gambling establishment. After a fire destroyed its upper floors in 1899 and Guthrie voting itself "dry", it was renovated into a one-story building. Its original concrete nameplate of the building, at the top of third floor, was reinstalled above its one story.