H2B

H2B could refer to:


 * A Honda powertrain modification consisting of a H series engine coupled to a B series drivetrain.
 * H-2B visa, a US program for temporary/seasonal, non-agricultural employment by foreign nationals.
 * Heavens to Betsy, a punk rock band from Olympia, Washington, USA.
 * Histone H2B, one of 5 main histone proteins involved in the structure of chromatin in eukaryotic cells.
 * H-IIB, a family of Japanese rockets.
 * Help to Buy, financial assistance for purchasing a home in the UK.