HD5

HD5 may refer to:


 * HD5 of MediaCorp TV in Singapore
 * HD5 of Euro1080 owned by Alfacam in Belgium
 * HD 5 (HIP 429, BD+01 4825), a star in the Henry Draper Catalogue. It is a G5 star located at (J2000.0; 00:05:10.1829; +02°23′49.949″)
 * Human Alpha Defensin 5, the DEFA5 gene product