HDAC1

Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.

Function
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

Interactions
HDAC1 has been shown to interact with:


 * Androgen receptor,
 * BCL6,
 * BTG2,
 * BUB1B,
 * BUB1,
 * BUB3,
 * CBFA2T3,
 * CDC20,
 * CDH1,
 * CHD3,
 * CHD4,
 * COUP-TFII,
 * CTBP1,
 * DDX17,
 * DDX5,
 * DNMT3A,
 * DNMT3L,
 * Death-associated protein 6,
 * EED,
 * EVI1,
 * EZH2,
 * FKBP3,
 * GATA1,
 * HMG20B,
 * HSPA4,
 * HUS1,
 * Histone deacetylase 2,
 * Homeobox protein TGIF1,
 * Host cell factor C1,
 * IFRD1,
 * IKZF1,
 * ING1,
 * MBD3,
 * MIER1,
 * MLL,
 * MTA1,
 * MTA2,
 * Mad1,
 * Mdm2,
 * Methyl-CpG-binding domain protein 2,
 * Mothers against decapentaplegic homolog 2,
 * MyoD,
 * NFKB1,
 * Nuclear receptor co-repressor 2,
 * P21,
 * PCNA,
 * PHF21A,
 * Prohibitin,
 * Promyelocytic leukemia protein,
 * RAD9A,
 * RBBP4,
 * RBBP7,
 * RCOR1,
 * RELA,
 * RFC1,
 * Retinoblastoma protein,
 * Retinoblastoma-like protein 1,
 * Retinoblastoma-like protein 2,
 * SAP30,
 * SATB1,
 * SIN3A,
 * SIN3B,
 * SPEN,
 * SUDS3,
 * SUV39H1,
 * Sp1 transcription factor,
 * TOP2A,
 * TOP2B,  and
 * Zinc finger and BTB domain-containing protein 16.