HDF

HDF may refer to:
 * Hadfield railway station (station code), in Derbyshire, England
 * Hauts-de-France, a region of France
 * Hereditary Disease Foundation, an American organization
 * Heringsdorf Airport (IATA code), near Garz on the island of Usedom, Germany
 * Hierarchical Data Format, a file format
 * High-density fiberboard, a type of very dense fibreboard, which is an engineered wood product
 * Hortonworks DataFlow, an open-source real-time streaming analytics software platform
 * Hôtel-Dieu de France, a Lebanese medical center
 * Hubble Deep Field, an astronomical image
 * Human Development Foundation, an organization in Thailand
 * Hungarian Defence Force, the national defence force of Hungary
 * Hydrodefluorination, a type of organic reaction