HDX

HDX may refer to:
 * HDX (Home Depot), in-house brand used by The Home Depot
 * Fire HDX, Amazon Fire tablet computer
 * Half-duplex, communication flowing in both directions, but not simultaneously
 * Humanitarian Data Exchange, an open humanitarian data sharing platform managed by the United Nations Office for the Coordination of Humanitarian Affairs
 * Hydrogen–deuterium exchange
 * Lisofylline, an experimental anti-inflammatory drug
 * Pro Tools HDX audio accelerator hardware
 * Thomas Saf-T-Liner HDX, an American school bus
 * Sky Sports HDX, a defunct Sky Sports HD channel brand