HGSC

HGSC may refer to:


 * Harvard Gender and Sexuality Caucus (formerly Harvard Gay and Lesbian Caucus), American non-profit organization of LGBT alumni/ae, faculty, staff and students
 * Human Genome Sequencing Center, human genetics center at Baylor College of Medicine in Houston, Texas
 * High-grade serous carcinoma, a type of epithelial tumour that makes up the majority of ovarian cancer cases