HME

HME may refer to:


 * HME, Incorporated, a U.S. custom truck manufacturer
 * Hereditary multiple exostoses
 * Human monocytotropic ehrlichiosis, an infectious disease
 * Home medical equipment
 * Hamble railway station, in England
 * Heat and moisture exchanger
 * Human macrophage metalloelastase, an enzyme
 * Hot melt extrusion
 * Hermes Aviation, a defunct airline of Malta
 * Home market effect
 * Huishui Miao, a language of China
 * Homemade explosive, often used in improvised explosive devices
 * Oued Irara–Krim Belkacem Airport, in Algeria
 * Humen railway station, China Railway pinyin code HME
 * Hazardous Materials Endorsement, a HAZMAT endorsement issued by the U.S. Transportation Security Administration