HPB

HPB may refer to:


 * Half Price Books, an American book retailer
 * Harvard Papers in Botany, a scientific journal
 * Health Promotion Board, a statutory board in Singapore for health promotion and disease prevention
 * Helena Petrovna Blavatsky (1831–1891), theosophist, writer and traveler
 * Hooper Bay Airport, in Alaska, United States (by IATA and FAA LID code)
 * Hrvatska poštanska banka, largest Croatian-owned bank
 * HPB (journal), journal of the International Hepato-Pancreato-Biliary Association
 * Hexaphenylbenzene