HPE

HPE may refer to:

Cars

 * Lancia Beta HPE, introduced 1975
 * Lancia Delta HPE, introduced 1995

Organizations

 * Hennessey Performance Engineering, American hypercar manufacturer
 * Hewlett Packard Enterprise, American multinational information technology company
 * United Alignment of Nationalists (Greek: Ηνωμένη Παράταξις Εθνικοφρόνων), a Greek political alliance
 * Êzîdxan Protection Force (Kurdish: Hêza Parastina Êzîdxanê, HPÊ)

Science and technology

 * High-pressure electrolysis
 * Holoprosencephaly, a cephalic disorder

Other uses

 * High Point Enterprise, a US newspaper
 * Hope railway station (Wales) (station code), in Flintshire, Wales