HPO

HPO may refer to:


 * HPO formalism, an approach to temporal quantum logic
 * Hamilton Philharmonic Orchestra, a symphony orchestra based in Ontario, Canada
 * High performance organization, a conceptual framework for organizations
 * Highway Post Office, of the United States Postal Service
 * Homeowner Protection Office, in British Columbia, Canada
 * Hpon language, spoken in Burma
 * Human Phenotype Ontology
 * Humanist Party of Ontario, a political party in Canada
 * Hydrogen peroxide, an oxidizer
 * Premnaspirodiene oxygenase, an enzyme
 * Hippo, a protein kinase involved in the Hippo signaling pathway
 * Hyperparameter optimization, a technique used in automated machine learning