HSR

HSR may refer to:

Biology and medicine

 * Health services research
 * Heat shock response, via HSPA1A gene
 * Homogeneously staining region

Transportation

 * Hamilton Street Railway, a transit agency in Canada
 * High-speed rail
 * Higher-speed rail
 * Hisar Junction railway station, in India
 * Holyoke Street Railway
 * Hot Springs Municipal Airport, South Dakota, US
 * Mitsubishi HSR, a concept car

Other

 * Haliburton Scout Reserve, a Scouts Canada camp
 * Hart–Scott–Rodino Antitrust Improvements Act
 * Hidden surface removal
 * Hierarchical state routing
 * High-availability Seamless Redundancy
 * High-Speed Research Program, a 1990-1999 NASA supersonic jet program
 * Historical Social Research
 * Historic Sportscar Racing, an American historic motorsport series
 * Hochschule für Technik Rapperswil, a university in St. Gallen, Switzerland
 * Honkai: Star Rail, a 2023 role-playing gacha game released by HoYoverse
 * HSR Layout, Bengaluru