Henry Middleton (disambiguation)

Henry Middleton may refer to:
 * Sir Henry Middleton (captain) (died 1613), English sea captain and adventurer
 * Henry Middleton (1717–1784), American plantation owner and public official from South Carolina
 * Henry Middleton (governor) (1770–1846), American politician from South Carolina
 * Henry A. Middleton (1888–1975), American lawyer from Ohio