Hippocalcin

Hippocalcin is a protein that in humans is encoded by the HPCA gene.

Hippocalcin is a calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins. It is expressed in mammalian brains especially in the hippocampus. It possesses a Ca2+/myristoyl switch.

Processes
Hippocalcin takes part in the following processes:


 * Activation of PLD1 and PLD2 expression
 * Inhibition of apoptosis
 * MAP kinase signalling
 * Involved in long term depression in hippocampal neuron
 * Required for normal spatial learning

Interactions
Hippocalcin interacts with following proteins:


 * Neuronal apoptosis inhibitory protein (NAIP)
 * Mixed lineage kinase 2 (MLK2) – MLK2 is myosin light chain kinase 2
 * The b2 adaptin of the AP2 complex
 * Calcium-dependent activator protein for secretion (CADPS)