Holston

Holston may refer to:


 * Holston, Virginia
 * Holston River
 * Holston Formation
 * Treaty of Holston
 * Holston Conference, an annual conference within Methodism
 * Holston Army Ammunition Plant in Kingsport, Tennessee
 * The Holston, an NRHP-listed high-rise in Knoxville, Tennessee

People with the surname

 * Alan Holston, British fashion entrepreneur
 * David Holston (born 1986), American basketball player
 * Mike Holston (born 1958), American football player