Homestake

Homestake may refer to:
 * Homestake experiment, an experiment headed by astrophysicists Raymond Davis, Jr. and John N. Bahcall in the late 1960s
 * Homestake Pass, a mountain pass in the Rocky Mountains of Montana in the United States
 * Homestake Mining Company, one of the largest gold mining businesses in the United States from the 19th century through the beginning of the 21st
 * Homestake Mine (disambiguation), the name for several mines in the United States
 * Homestake, a formation on Mars analyzed by Opportunity rover, which was concluded to be formed of gypsum