Homoserine O-succinyltransferase

In enzymology, a homoserine O-succinyltransferase is an enzyme that catalyzes the chemical reaction


 * succinyl-CoA + L-homoserine $$\rightleftharpoons$$ CoA + O-succinyl-L-homoserine

Thus, the two substrates of this enzyme are succinyl-CoA and L-homoserine, whereas its two products are CoA and O-succinyl-L-homoserine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is succinyl-CoA:L-homoserine O-succinyltransferase. Other names in common use include homoserine O-transsuccinylase, and homoserine succinyltransferase. This enzyme participates in methionine metabolism and sulfur metabolism.

Structural studies
As of late 2016, three structures have been solved for this class of enzymes, with PDB accession codes, , and.