Hotel DeFair

The Hotel DeFair, at NE 2 and Main St. in Hyannis, Nebraska, and also known as the Hyannis Hotel, was built in 1898 and is listed on the National Register of Historic Places (NRHP). According to its NRHP nomination, it once was considered to be the best hotel and restaurant in western Nebraska.

The building design includes Greek Revival and Second Empire architectural elements.

The hotel was listed on the National Register of Historic Places in 1976.