Hughes Creek (Apple Creek tributary)

Hughes Creek is a stream in Cape Girardeau County in the U.S. state of Missouri. It is a tributary of Apple Creek.

The stream headwaters arise just west of Oak Ridge (at 37.49972°N, -89.73278°W) and the stream flows to the northeast passing under I-55 and U.S. Route 61 to its confluence with Apple Creek about two miles southeast of Old Appleton at 37.58444°N, -89.6775°W.

Hughes Creek has the name of a pioneer citizen.