Hyaluronate lyase

The enzyme hyaluronate lyase catalyzes the chemical reaction


 * Cleaves hyaluronate chains at a β- D -GalNAc-(1→4)-β- D -GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-β- D -gluc-4-enuronosyl)-N-acetyl-D-glucosamine

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on polysaccharides. The systematic name of this enzyme class is hyaluronate lyase. Other names in common use include hyaluronidase (ambiguous), (hyalurononglucosaminidase) (ambiguous), (hyaluronoglucuronidase)], glucuronoglycosaminoglycan lyase, spreading factor, and mucinase (ambiguous).

Structural studies
As of late 2007, 27 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , , , , , , , , , , , , , , , , , , and.