Hydrazine (antidepressant)



The hydrazine antidepressants are a group of non-selective, irreversible monoamine oxidase inhibitors (MAOIs) which were discovered and initially marketed in the 1950s and 1960s. Most have been withdrawn due to toxicity, namely hepatotoxicity, but a few still remain in clinical use.

Tranylcypromine, a structurally unrelated MAOI introduced around the same time as the hydrazines, was originally advertised as non-hydrazine as a result of its diminished propensity for causing hepatotoxicity.

Marketed

 * Benmoxin (Neuralex, Nerusil) ‡
 * Iproclozide (Sursum) ‡
 * Iproniazid (Marsilid) ‡
 * Isocarboxazid (Marplan)
 * Mebanazine (Actomol) ‡
 * Nialamide (Niamid) ‡
 * Octamoxin (Ximaol, Nimaol) ‡
 * Phenelzine (Nardil)
 * Pheniprazine (Catron) ‡
 * Phenoxypropazine (Drazine) ‡
 * Pivhydrazine (Tersavid) ‡
 * Safrazine (Safra) ‡

Legend: ‡ = Withdrawn from the market; † = Partially discontinued; Bolded names indicate major drugs.

Never marketed

 * Carbenzide
 * Cimemoxin
 * Domoxin
 * Metfendrazine

Parkinson's

 * Carbidopa

Tranquillosedative

 * Centazolone