Hypocretin (orexin) receptor 1

Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1 (HcrtR1), is a protein that in humans is encoded by the HCRTR1 gene.

Function
The orexin 1 receptor (OX1), is a G-protein coupled receptor that is heavily expressed in projections from the lateral hypothalamus and is involved in the regulation of feeding behaviour. OX1 selectively binds the orexin-A neuropeptide. It shares 64% identity with OX2.

Agonists

 * Orexin-A

Antagonists

 * RTIOX-276 - Selective OX1 antagonist
 * ACT-335827 - Selective OX1 antagonist
 * Almorexant - Dual OX1 and OX2 antagonist
 * Lemborexant - Dual OX1 and OX2 antagonist
 * Nemorexant - Dual OX1 and OX2 antagonist
 * SB-334,867 - Selective OX1 antagonist
 * SB-408,124 - Selective OX1 antagonist
 * SB-649,868 - Dual OX1 and OX2 antagonist
 * Suvorexant - Dual OX1 and OX2 antagonist