ISC

ISC may refer to:

Arts and entertainment

 * Imperial Space Command, a fictional organization in the books by Catherine Asaro
 * Indian Society of Cinematographers, a non-profit cultural and educational organisation
 * Intervision Song Contest, an Eastern Bloc version of the Eurovision Song Contest from the 1970s and 1980s
 * Iraq-Syria Caliphate or simply ISC, fictional terrorist organization (based on ISIS) in the 2017 Indian film Tiger Zinda Hai

Science and technology

 * Induced stem cells
 * International Science Council, a non-governmental organization uniting scientific bodies
 * International Seismological Centre, a seismology data center
 * Intersystem crossing, an excited state dynamic in chemistry and physics
 * Iron–sulfur cluster biosynthesis protein family, machinery for producing iron–sulfur clusters

Computing

 * Initiative for Software Choice, a group of software vendors
 * Interactive Systems Corporation, a defunct Unix vendor
 * Internet Storm Center, a program run by the SANS Institute that monitors the level of malicious activity on the Internet
 * International Supercomputing Conference, a yearly conference on Supercomputing which has been held in Europe
 * Inverse Symbolic Calculator
 * Internet Systems Consortium, an organization that develops Internet software
 * ISC license, a free software license introduced by the Internet Systems Consortium

Education

 * Independent Schools Council, a British organization representing independent schools
 * Indian School Certificate, a national level examination for the upper years (Classes XI and XII) of high school
 * Information Systems and Controls in the Uniform Certified Public Accountant Examination
 * Institut supérieur du commerce de Paris, a French business school
 * International School of Carthage, a private school in Tunis, Tunisia
 * International School of Curitiba, a school in Curitiba, Brazil
 * International Students' Committee, organizers of the St. Gallen Symposium in Switzerland
 * International Student Conference, a nonpartisan rival organization to the International Union of Students
 * Islamic World Science Citation Database, Iranian regional citation index

Sports

 * International Shooto Commission, an international commission of combat sports called MMA
 * International Softball Congress, a North American softball tournament organization
 * International Speedway Corporation, former auto racing race track owner; merged with NASCAR in 2019
 * ISC (sportswear), an Australian sports apparel manufacturer
 * International Sportsworld Communicators, the owner of the commercial rights to the World Rally Championship
 * Indonesia Soccer Championship, a football league system in Indonesia
 * Indonesia Soccer Championship A, a top-tier league
 * Indonesia Soccer Championship B, a second-tier league

Other organizations

 * Indigenous Services Canada
 * Infiltration Surveillance Center, the defunct command center for Operation Igloo White in Nakhon Phanom, Thailand
 * Intelligence and Security Committee, a committee of the UK Parliament
 * International Signal and Control, an American defense contractor
 * International Socialist Commission
 * International Silver Company, a corporation banding together many existing silver companies in Connecticut
 * Information Services Corporation, a corporation responsible for the development, management and administration of: registries – land titles, personal property, corporate and survey registries in Saskatchewan
 * Kandersteg International Scout Centre, Switzerland

Other uses

 * Internet Scrabble Club, an online Scrabble website
 * St Mary's Airport, Isles of Scilly (IATA airport code), an airport in the Isles of Scilly
 * International service center, a type of United States Postal Service facility