Iboga-type alkaloid

Iboga-type alkaloids are a set of monoterpene indole alkaloids comprising naturally occurring compounds found in Tabernanthe and Tabernaemontana, as well as synthetic structural analogs. Naturally occurring iboga-type alkaloids include ibogamine, ibogaine, tabernanthine, and other substituted ibogamines. Many iboga-type alkaloids display biological activities such as cardiac toxicity and psychoactive effects, and some have been studied as potential treatments for drug addiction.

Substituted ibogamines
Catharanthine is an unsaturated analog of coronaridine.

Oxidation products
Similarly to other ring-constrained tryptamines such as yohimbine and mitragynine (see mitragynine pseudoindoxyl), oxidation and rearrangement products of substituted ibogamines have been reported, such as iboluteine (ibogaine pseudoindoxyl) (CID:21589055) and voaluteine (CID:633439).

Other alkaloids

 * Vobasine
 * Ervaticine
 * Dregamine
 * Vinblastine

Synthetic analogs
18-MC, ME-18-MC, and 18-MAC are coronaridine analogs with similar anti-addictive effects.

More distantly related synthetic analogs include :
 * Varenicline, a polycyclic azepine and anti-addictive agent that similarly targets nicotinic acetylcholine receptors, but acts as a partial agonist instead.
 * Tabernanthalog is a structural simplification of tabernanthine and "non-hallucinogenic psychoplastogen".