Immunoglobulin I-set domain

I-set domains are found in several cell adhesion molecules, including vascular (VCAM), intercellular (ICAM), neural (NCAM) and mucosal addressin (MADCAM) cell adhesion molecules, as well as junction adhesion molecules (JAM). I-set domains are also present in several other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signalling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.

Human proteins containing this domain

 * ADAMTSL1, ADAMTSL3, ALPK3, AXL,
 * BOC,
 * C9orf94, CADM2, CADM4, CCDC141, CDON, CEACAM7, CHL1, CILP2, CNTN1, CNTN2, CNTN3, CNTN4, CNTN5, CNTN6, CXADR,
 * DCC, DSCAM, DSCAML1,
 * ESAM,
 * FGFR1, FGFR3, FGFR4, FGFRL1, FLT1, FLT4, FSTL4, FSTL5,
 * HMCN1, HNT, HSPG2,
 * ICAM5, IGFBP7, IGFBPL1, IGSF10, IGSF22, IGSF9, ISLR,
 * KALRN, KAZALD1, KDR, KIAA0626, KIRREL, KIRREL2, KIRREL3,
 * L1CAM, LINGO1, LINGO2, LRFN2, LRFN3, LRFN4, LRFN5, LRIG1, LRIG2, LRIG3, LRIT2, LRIT3, LRRC24, LRRC4B, LRRC4C, LRRN1, LRRN3, LRRN5, LSAMP,
 * MAG, MDGA2, MFAP3L, MUSK, MXRA5, MYBPC1, MYBPC2, MYBPC3, MYBPH, MYBPHL, MYLK, MYOM1, MYOM2, MYOM3, MYOT, MYPN,
 * NCAM1, NCAM2, NEGR1, NEO1, NEXN, NFASC, NGL1, NOPE, NPHS1, NPTN, NRCAM, NRG2, NT, NTRK2, NTRK3,
 * OBSCN, OBSL1, OPCML,
 * PALLD, PAPLN, PDGFRA, PRODH2, PTK7, PTPRD, PTPRF, PTPRS, PTPsigma, PUNC,
 * ROBO1, ROBO2, ROBO3, ROBO4, ROR1, ROR2,
 * SDK1, SDK2, SIGLEC1, SIGLEC6, SPEG,
 * TRIO, TTN,
 * UNC5A, UNC5B, UNC5C,
 * VCAM1, WFIKKN1, WFIKKN2,