Immunoglobulin V-set domain

V-set domains are Ig-like domains resembling the antibody variable domain. V-set domains are found in diverse protein families, including immunoglobulin light and heavy chains; in several T-cell receptors such as CD2 (Cluster of Differentiation 2), CD4, CD80, and CD86; in myelin membrane adhesion molecules; in junctional adhesion molecules (JAM); in tyrosine-protein kinase receptors; and in the programmed cell death protein 1 (PD1).

Subfamilies

 * Immunoglobulin V-set, subgroup
 * T-cell surface antigen CD2

Human proteins containing this domain
ACAM;     ACAN;      ADAMTSL1;  AGC1;      AMICA1;    BCAM;      BCAN;      BGP; BGPc;     BT3.3;     BTN1A1;    BTN2A1;    BTN2A2;    BTN2A3;    BTN3A1;    BTN3A2; BTN3A3;   BTNL2;     BTNL3;     BTNL8;     BTNL9;     C10orf54;  C1orf32;   C9orf94; CADM1;    CADM2;     CADM3;     CADM4;     CD2;       CD226;     CD274;     CD276; CD300A;   CD300C;    CD300D;    CD300E;    CD300LB;   CD300LF;   CD300LG;   CD33; CD3G;     CD7;       CD79A;     CD79B;     CD80;      CD83;      CD86;      CD8A; CD8B;     CD8B1;     CD96;      CEACAM1;   CEACAM16;  CEACAM19;  CEACAM21;  CEACAM3; CEACAM4;  CEACAM5;   CEACAM6;   CEACAM7;   CEACAM8;   CHL1;      CREA7-4;   CRTAM; CSF1R;    CTLA4;     CXADR;     ERMAP;     ESAM;      F11R;      FCAMR;     FCRL2; FKSG87;   GLUDP5;    GPA33;     HAPLN1;    HAPLN2;    HAPLN3;    HAPLN4;    HAVCR1; HEPACAM;  HHLA2;     HSPG2;     ICOSLG;    IGHA1;     IGHA2;     IGHD;      IGHG1; IGHG3;    IGHM;      IGHV1-69;  IGHV4-31;  IGHV7-81;  IGKC;      IGKV1-5;   IGKV2-24; IGL@;     IGLC1;     IGLV2-14;  IGLV3-21;  IGLV3-25;  IGLV4-3;   IGLV5-52;  IGLV6-57; IGSF11;   IGSF2;     IGSF3;     IGSF6;     IGSF8;     IGSF9;     IL18R1;    IREM2; IREM3;    JAM2;      JAM3;      KDR;       KIRREL;    KIRREL2;   KIRREL3;   LAG3; LOC253012; LOC402482; MAG;      MGC33530;  MOG;       MPZ;       MPZL1;     MPZL2; MXRA8;    MYBPC3;    NCA;       NCR2;      NCR3;      NPHS1;     OBSL1;     OPCML; P0;       PDCD1;     PIGR;      PILRA;     PILRB;     PRODH2;    PSG1;      PSG10; PSG11;    PSG11s';   PSG2;      PSG3;      PSG4;      PSG5;      PSG6;      PSG7; PSG8;     PSG9;      PTGFRN;    PTPN1L;    PVR;       PVRL1;     PVRL2;     PVRL3; PVRL4;    SCN2B;     SCN3B;     SCN4B;     SEMA3D;    SIGLEC1;   SIGLEC10;  SIGLEC11; SIGLEC12; SIGLEC14;  SIGLEC15;  SIGLEC6;   SIGLEC7;   SIGLEC8;   SIGLEC9;   SIRPA; SIRPB1;   SIRPD;     SIRPG;     SISP1;     SLAMF6;    SLAMF7;    TAPBPL;    TCRA; TCRB;     TIMD4;     TRA@;      TRAV20;    TRBC1;     TRBV19;    TRBV3-1;   TRBV5-4; TRBV7-2;  TRDV2;     TREM1;     TREM2;     TREML1;    TREML2;    TREML4;    TRGV3; TRGV5;    TRGV7;     TRGV9;     VCAM1;     VCAN;      VPREB1;    VPREB3;    VSIG1; VSIG2;    VSIG4;     VSIG9;     VSIG10;    VSTM1;     VSTM2;     VTCN1;