Immunoglobulin domain

The immunoglobulin domain, also known as the immunoglobulin fold, is a type of protein domain that consists of a 2-layer sandwich of 7-9 antiparallel β-strands arranged in two β-sheets with a Greek key topology, consisting of about 125 amino acids.

The backbone switches repeatedly between the two β-sheets. Typically, the pattern is (N-terminal β-hairpin in sheet 1)-(β-hairpin in sheet 2)-(β-strand in sheet 1)-(C-terminal β-hairpin in sheet 2). The cross-overs between sheets form an "X", so that the N- and C-terminal hairpins are facing each other.

Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin, and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein–protein and protein–ligand interactions.

Examples
Human genes encoding proteins containing the immunoglobulin domain include:


 * A1BG
 * ACAM
 * ADAMTSL1
 * ADAMTSL3
 * AGER
 * ALCAM
 * AMIGO1
 * AMIGO2
 * AXL
 * BCAM
 * BOC
 * BSG
 * BTLA
 * C10orf72
 * C20orf102
 * CADM1
 * CADM3
 * CD200
 * CD22
 * CD276
 * CD33
 * CD4
 * CDON
 * CEACAM1
 * CEACAM16
 * CEACAM20
 * CEACAM21
 * CEACAM5
 * CEACAM6
 * CEACAM8
 * CHL1
 * CILP
 * CNTFR
 * CNTN1
 * CNTN2
 * CNTN3
 * CNTN4
 * CNTN5
 * CNTN6
 * CSF1R
 * DSCAM
 * DSCAML1
 * EMB
 * F11R
 * FAIM3
 * FCAR
 * FCER1A
 * FCGR1A
 * FCGR2A
 * FCGR2B
 * FCGR2C
 * FCGR3A
 * FCGR3B
 * FCRH1
 * FCRH3
 * FCRH4
 * FCRL1
 * FCRL2
 * FCRL3
 * FCRL4
 * FCRL5
 * FCRL6
 * FCRLA
 * FGFR1
 * FGFR2
 * FGFR3
 * FGFR4
 * FGFRL1
 * FLT1
 * FLT3
 * FLT4
 * FSTL4
 * FSTL5
 * GP6
 * GPA33
 * GPR116
 * GPR125
 * HEPACAM
 * HLA-DMA
 * HLA-DMB
 * HLA-DQB
 * HLA-DQB1
 * HMCN1
 * HNT
 * HSPG2
 * HYST2477
 * ICAM3
 * ICAM5
 * IGHA1
 * IGHD
 * IGHE
 * IGSF10
 * IGSF11
 * IGSF2
 * IGSF21
 * IGSF3
 * IGSF9
 * IL11RA
 * IL1R1
 * IL1R2
 * IL1RAPL1
 * IL1RAPL2
 * IL1RL1
 * IL1RL2
 * IL6R
 * JAM2
 * JAM3
 * KIR-123FM
 * KIR2DL1
 * KIR2DL2
 * KIR2DL3
 * KIR2DL4
 * KIR2DL5A
 * KIR2DL5B
 * KIR2DLX
 * KIR2DS1
 * KIR2DS2
 * KIR2DS3
 * KIR2DS4
 * KIR2DS5
 * KIR3DL1
 * KIR3DL2
 * KIR3DL3
 * KIR3DS1
 * KIT
 * L1CAM
 * LAG3
 * LILRA1
 * LILRA2
 * LILRA3
 * LILRA4
 * LILRA5
 * LILRA6
 * LILRB1
 * LILRB2
 * LILRB3
 * LILRB4
 * LILRB5
 * LILRP2
 * LRIG1
 * LRIG2
 * LRIG3
 * LRIT1
 * LRRC4
 * LSAMP
 * MAG
 * MALT1
 * MCAM
 * MDGA1
 * MDGA2
 * MERTK
 * MFAP3
 * MIR
 * MIR
 * MXRA5
 * MYBPC3
 * MYOM1
 * MYOM3
 * NCA
 * NCAM1
 * NCAM2
 * NEGR1
 * NEO1
 * NFASC
 * NOPE
 * NPHS1
 * NPTN
 * NRCAM
 * NRG1
 * NT
 * NTRK3
 * OBSCN
 * OBSL1
 * OPCML
 * PAPLN
 * PDGFRA
 * PDGFRB
 * PDGFRL
 * PECAM1
 * PRODH2
 * PSG1
 * PSG10
 * PSG11
 * PSG11s'
 * PSG2
 * PSG3
 * PSG4
 * PSG5
 * PSG6
 * PSG7
 * PSG8
 * PSG9
 * PTGFRN
 * PTK7
 * PTPRD
 * PTPRK
 * PTPRM
 * PTPRS
 * PTPsigma
 * PUNC
 * PVR
 * PVRL1
 * PVRL2
 * PVRL4
 * RAGE
 * SCN1B
 * SDK1
 * SDK2
 * SEMA3A
 * SEMA3B
 * SEMA3E
 * SEMA3F
 * SEMA3G
 * SEMA4D
 * SIGLEC1
 * SIGLEC10
 * SIGLEC11
 * SIGLEC12
 * SIGLEC14
 * SIGLEC6
 * SIGLEC7
 * SIGLEC8
 * SIRPG
 * THY1
 * TIE1
 * TMIGD1
 * TMIGD2
 * TTN
 * TYRO3
 * UNC5D
 * VCAM1
 * VSIG1
 * VSIG2
 * VSIG4
 * hEMMPRIN
 * kir3d