Integral monotopic protein



Integral monotopic proteins are permanently attached to the cell membrane from one side, and are a type of integral membrane protein (IMP).

Three-dimensional structures of the following integral monotopic proteins have been determined:
 * prostaglandin H2 syntheses 1 and 2 (cyclooxygenases)
 * lanosterol synthase and squalene-hopene cyclase
 * microsomal prostaglandin E synthase
 * carnitine O-palmitoyltransferase 2
 * Phosphoglycosyl transferase C

There are also structures of integral monotopic domains of transmembrane proteins:
 * monoamine oxidases A and B
 * fatty acid amide hydrolase
 * mammalian cytochrome P450 oxidases
 * corticosteroid 11-beta-dehydrogenases