Irene Palaiologina

Irene Palaiologina or Palaeologina (Ειρήνη Παλαιολογίνα) may refer to:


 * Irene Palaiologina, Empress of Bulgaria, daughter of Michael VIII Palaiologos, Empress-consort of Bulgaria in 1279–80
 * Irene Palaiologina, illegitimate daughter of Andronikos II Palaiologos, wife of John II Doukas of Epirus
 * Irene Palaiologina of Trebizond, illegitimate daughter of Andronikos III Palaiologos, reigning Empress of Trebizond in 1340–41
 * Irene Palaiologina (Byzantine empress), Empress-consort of Matthew Kantakouzenos
 * Maria-Irene Palaiologina
 * Irene Palaiologina, daughter of Helena Kantakouzene and wife of Khalil of Bithynia, son of Orhan I with Helena's sister, Theodora Kantakouzenos.
 * Irene Palaiologina, mother of Theodora Raoulaina
 * Irene Palaiologina, daughter of Lazar Branković and Helena Palaiologina