Isaac McCormick House

Isaac McCormick House, also known as McCormick Farm, is a historic home located near Defiance, St. Charles County, Missouri. It was built about 1867, and is a two-story, "L"-plan, log dwelling. It consists of a single pen hewn log main section with single pen hewn log ell. The main section measures approximately 18 feet wide and 27 feet deep and has a side gable roof.

It was added to the National Register of Historic Places in 2004.