Isom (surname)

Isom is a surname. Notable people with the name include:


 * Anne Williams-Isom (born 1967), American government official, academic, lawyer, and nonprofit executive
 * Cedric Isom (born 1984), American-Rwandan basketball player
 * Daniel Isom (born 1967), American academic and police officer
 * Harriet Winsar Isom (born 1936), American foreign service officer
 * Lori L. Isom, American pharmacologist
 * Mary Frances Isom (1865–1920), American librarian
 * Mike Isom (born 1948), American football coach
 * Mo Isom (born 1989), American soccer player
 * Ray Isom (born 1965), American football player
 * Rickey Isom (born 1963), American football player
 * Sarah McGehee Isom (1854–1905), American orator