Issac

Issac may refer to:

Given name

 * Issac Amaldas, Indian boxer
 * Issac Bailey, American writer
 * Issac Blakeney (born 1992), American football wide receiver
 * Issac Booth (born 1971), American football player
 * Issac Ryan Brown (born 2005), American child actor and singer
 * Issac Delgado (born 1962), Cuban-Spanish musician, and salsa performer
 * Issac Honey (born 1993), Ghanaian footballer
 * Issac Koga (1899–1982), Japanese electronics researcher/engineer
 * Issac Luke (born 1987), New Zealand rugby league hooker
 * Issac Osae (born 1993), Ghanaian footballer

Surname

 * Osthatheos Issac (born 1976), Syriac Orthodox bishop
 * Rod Issac (born 1989), American football cornerback

Places

 * Issac, Dordogne, a commune in France.