Issus

Issus may refer to:


 * Issus (Cilicia), an ancient settlement in the modern Turkish province of Hatay
 * Battle of Issus (333 BC), in which Alexander the Great of Macedonia defeated Darius III of Persia
 * Battle of Issus (194), in which P. Cornelius Anullinus defeated Septimius Severus's rival Pescennius Niger
 * Battle of Issus (622), in which the Byzantine emperor Heraclitus defeated Shahrbaraz of Persia
 * Issus (diocese), a Roman Catholic titular see in the town
 * Issus (river), a river near the town and battle site
 * Gulf of Issus, near the town
 * Issus, Haute-Garonne, a commune in France
 * Issus (planthopper), a genus of planthoppers in the family Issidae
 * Issus, the ostensible Goddess of Death and Eternal Life in the Barsoom series of novels