JSC

JSC may refer to:


 * Jane Street Capital, a proprietary trading firm
 * JavascriptCore, a framework that provides a JavaScript engine for WebKit implementations
 * Jeffree Star Cosmetics, an American cosmetics franchise
 * Johnson Space Center, NASA facility at Houston, Texas, United States
 * Johnson State College, one of the Vermont State Colleges, United States
 * Joint Staff College
 * Joint-stock company, a type of business entity
 * Jubilee Sports Centre, the former name of the Hong Kong Sports Institute
 * Judicial Service Commission (disambiguation), the body tasked with appointing judges in several Commonwealth countries
 * Julio Sánchez Cristo, a Latin American radio personality
 * Junior School Certificate, a public examination in Bangladesh
 * Postnomial letters for a Judge of the New Jersey Superior Court
 * Al Jazeera Satellite Channel, a broadcaster in Doha, Qatar, owned by the Al Jazeera Media Network