James C. Self House

James C. Self House is a historic home in Greenwood, South Carolina, designed by local architect Thomas White Cothran (1874-1923) for textile magnate and philanthropist James Cuthbert Self (1876-1955) and built in 1917–1918. The house is a two-story, brick veneer Neoclassical style dwelling with a green Spanish tile hipped roof. It sits on a brick foundation faced with rock and an Ionic order portico that projects from the three central bays. The property includes a smokehouse/wellhouse and garage.

It was listed on the National Register of Historic Places in 1987.